1-1.5 mg of protamine per 100 standard units heparin.Standard heparin administered subcutaneously:.Repeat the APTT 5 to 15 min after the end of the IV infusion and 2 hours later (possible rebound with heparin) to assess whether an additional dose is required. Adjust the dose if necessary, depending on effect.Administer an empirical dose of 25-50 mg of protamine IV infusion over 10 min.APTT unavailable heparin dose unknown:.TIME SINCE THE INJECTION OF HEPARIN DIRECT IVĭOSE OF PROTAMINE RECOMMENDED FOR EACH 100 UNITS OF STANDARD HEPARIN APPT unavailable heparin dose known (administer by direct IV only):.Administer the dose by IV infusion over 10 min.E.g.: To neutralize 3875 standard heparin units, administer approx.Determine the dose of protamine to administer:.Example: For a patient receiving a continuous IV infusion of standard heparin of 1500 units/h with a 5000 unit bolus 3 hrs ago, should neutralize: + + = 3875 units to neutralize.Include all bolus doses and the continuous infusion in the calculation.Calculate the amount of heparin to neutralize:.Consider the elimination half-life of standard heparin is about 1 hr.APPT unavailable heparin dose known (continuous IV infusion):.Repeat the APTT 5-15 min after the end of the IV infusion and 2 hrs later (possibility of rebound with heparin) to assess whether an additional dose is required. APTT 300-400 secs: 1.2 mg/kg protamine (max 50 mg/dose) by IV infusion over 10 min.APTT 200-300 secs: 0.6 mg/kg protamine (max 50 mg/dose) by IV infusion over 10 min.Available activated partial thromboplastin time (APTT):.WARNING: The dose of protamine to be administered should be calculated based on the remaining amount of anticoagulant to be neutralized. Évaluation des technologies et des modes d'intervention.Centre d’expertise en sécurité de l’information (CESS).Centre d'excellence sur le vieillissement de Québec.Colloques, congrès, conférences et formations.

Naloxone (extrahospital administration).Chelating agents (excluding Deferoxamine).Accès au dossier de l'usager - Archives.Soins palliatifs et soins de fin de vie.Bank of Interpreters of the Capitale-Nationale.Comités des usagers (CU) et comités de résidents (CR).Devenir fournisseur pour le CIUSSS de la Capitale-Nationale.Bureau du partenariat avec l’usager et de l’éthique (BPUE).Portrait of the CIUSSS de la Capitale-Nationale.

Protamine sulfate antidote